Synthesis and anti-inflammatory evaluation of novel piperazine derivatives of mefenamic acid
نویسنده
چکیده
In order to explore novel anti-inflammatory agents, some novel mefenamic acid derivatives as potential non-steroidal antiinflammatory agents (NSAIDs) were synthesized and characterized by IR, H-NMR, C-NMR, mass and elemental analysis. The anti-inflammatory activities of the target compounds were evaluated via the croton oil-induced ear oedema test in mice. According to screened results, compounds I and II show potential anti-inflammatory activity comparable to aspirin.
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